Structures and molecular mechanisms for common 15q13.3 microduplications involving CHRNA7: benign or pathological?

Abstract

We have investigated four approximately 1.6-Mb microduplications and 55 smaller 350-680-kb microduplications at 15q13.2-q13.3 involving the CHRNA7 gene that were detected by clinical microarray analysis. Applying high-resolution array-CGH, we mapped all 118 chromosomal breakpoints of these microduplications. We also sequenced 26 small microduplication… (More)
DOI: 10.1002/humu.21284

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