Structures and mechanisms of enzymes in the leukotriene cascade.

@article{RinaldoMatthis2010StructuresAM,
  title={Structures and mechanisms of enzymes in the leukotriene cascade.},
  author={Agnes Rinaldo-Matthis and Jesper Z. Haeggstr{\"o}m},
  journal={Biochimie},
  year={2010},
  volume={92 6},
  pages={
          676-81
        }
}
Leukotrienes are a family of proinflammatory lipid mediators of the innate immune response and are important signaling molecules in inflammatory and allergic conditions. The leukotrienes are formed from arachidonic acid, which is released from membranes by cPLA(2), and further converted by 5-lipoxygenase to form the labile epoxide leukotriene (LT) A(4). This intermediate is converted by either of the two enzymes, LTA(4) hydrolase or LTC(4) synthase, to form LTB(4) or LTC(4), respectively. In… CONTINUE READING

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