Structured mRNAs Regulate Translation Initiation by Binding to the Platform of the Ribosome

@article{Marzi2007StructuredMR,
  title={Structured mRNAs Regulate Translation Initiation by Binding to the Platform of the Ribosome},
  author={Stefano Marzi and Alexander G. Myasnikov and Alexander Serganov and Chantal Ehresmann and Pascale Romby and Marat Yusupov and Bruno P. Klaholz},
  journal={Cell},
  year={2007},
  volume={130},
  pages={1019-1031}
}
Gene expression can be regulated at the level of initiation of protein biosynthesis via structural elements present at the 5' untranslated region of mRNAs. These folded mRNA segments may bind to the ribosome, thus blocking translation until the mRNA unfolds. Here, we report a series of cryo-electron microscopy snapshots of ribosomal complexes directly visualizing either the mRNA structure blocked by repressor protein S15 or the unfolded, active mRNA. In the stalled state, the folded mRNA… CONTINUE READING