Structure validation of the Josephin domain of ataxin-3: conclusive evidence for an open conformation.

@article{Nicastro2006StructureVO,
  title={Structure validation of the Josephin domain of ataxin-3: conclusive evidence for an open conformation.},
  author={Giuseppe Nicastro and Michael Habeck and Laura Masino and Dmitri I. Svergun and Annalisa Pastore},
  journal={Journal of biomolecular NMR},
  year={2006},
  volume={36 4},
  pages={267-77}
}
The availability of new and fast tools in structure determination has led to a more than exponential growth of the number of structures solved per year. It is therefore increasingly essential to assess the accuracy of the new structures by reliable approaches able to assist validation. Here, we discuss a specific example in which the use of different complementary techniques, which include Bayesian methods and small angle scattering, resulted essential for validating the two currently available… CONTINUE READING