Structure to function relationships in ceruloplasmin: a 'moonlighting' protein

  title={Structure to function relationships in ceruloplasmin: a 'moonlighting' protein},
  author={Pamela Bielli and Lilia Calabrese},
  journal={Cellular and Molecular Life Sciences CMLS},
Specialised copper sites have been recruited during evolution to provide long-range electron transfer reactivity and oxygen binding and activation in proteins destined to cope with oxygen reactivity in different organisms. Ceruloplasmin is an ancient multicopper oxidase evolved to insure a safe handling of oxygen in some metabolic pathways of vertebrates. The presently available knowledge of its structure provides a glimpse of its plasticity, revealing a multitude of binding sites that point to… CONTINUE READING

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