Structure-specific glial response in a macaque model of neuroAIDS: multivoxel proton magnetic resonance spectroscopic imaging at 3 Tesla

@article{Wu2013StructurespecificGR,
  title={Structure-specific glial response in a macaque model of neuroAIDS: multivoxel proton magnetic resonance spectroscopic imaging at 3 Tesla},
  author={W. E. Wu and A. Tal and K. Zhang and J. Babb and Eva-Maria Ratai and R. Gonz{\'a}lez and O. Gonen},
  journal={AIDS},
  year={2013},
  volume={27},
  pages={2519–2528}
}
  • W. E. Wu, A. Tal, +4 authors O. Gonen
  • Published 2013
  • Medicine
  • AIDS
  • Objective:As ∼40% of persons with HIV also suffer neurocognitive decline, we sought to assess metabolic dysfunction in the brains of simian immunodeficiency virus (SIV)-infected rhesus macaques, an advanced animal model, in structures involved in cognitive function. We test the hypothesis that SIV-infection produces proton-magnetic resonance spectroscopic imaging (1H-MRSI)-observed decline in the neuronal marker, N-acetylaspartate (NAA), and elevations in the glial marker, myo-inositol (mI… CONTINUE READING

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 59 REFERENCES
    Global gray and white matter metabolic changes after simian immunodeficiency virus infection in CD8‐depleted rhesus macaques: proton MRS imaging at 3 T
    • 4
    • PDF
    Magnetic resonance spectroscopy reveals that activated monocytes contribute to neuronal injury in SIV neuroAIDS.
    • 120
    • PDF
    Regional patterns of brain metabolites in AIDS dementia complex
    • 86