Structure-solubility relationship and thermal decomposition of furosemide.

  title={Structure-solubility relationship and thermal decomposition of furosemide.},
  author={H Beyers and Sarel F Malan and J G van der Watt and Melgardt M de Villiers},
  journal={Drug development and industrial pharmacy},
  volume={26 10},
Furosemide, a high ceiling diuretic, decomposes on heating and is very sparingly soluble in water. The aim of this study was to identify the thermal decomposition product(s) of furosemide and to calculate the activation energy needed for this reaction. This was done to gain a better understanding of the unusually low water solubility of this drug. The main thermal decomposition product was identified by nuclear magnetic resonance (NMR), mass spectrometry (MS), and infrared (IR) analysis as 4… CONTINUE READING