Structure-reactivity studies of the Cu(2+)-catalyzed decomposition of four S-nitrosothiols based around the S-Nitrosocysteine/S-nitrosoglutathione structures.

@article{Noble2000StructurereactivitySO,
  title={Structure-reactivity studies of the Cu(2+)-catalyzed decomposition of four S-nitrosothiols based around the S-Nitrosocysteine/S-nitrosoglutathione structures.},
  author={D. R. Noble and D. L. Williams},
  journal={Nitric oxide : biology and chemistry},
  year={2000},
  volume={4 4},
  pages={
          392-8
        }
}
  • D. R. Noble, D. L. Williams
  • Published 2000
  • Chemistry, Medicine
  • Nitric oxide : biology and chemistry
  • S-Nitrosoglutathione (GSNO) and the dipeptide derivative S-nitrosoglutamylcysteine (SNO-GluCys) both at 1 x 10(-3) M in pH 7. 4 buffer containing added Cu(2+) (1 x 10(-5) M) are very unreactive toward decomposition (measured spectrophotometrically), and in both cases reaction stops at very low conversion. S-Nitrosocysteine (SNC) and the dipeptide derivative S-nitrosocysteinylglycine (SNO-CysGly), on the other hand, are orders of magnitude more reactive under the same conditions, and reaction… CONTINUE READING
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