Structure of yeast Dom34: a protein related to translation termination factor Erf1 and involved in No-Go decay.

@article{Graille2008StructureOY,
  title={Structure of yeast Dom34: a protein related to translation termination factor Erf1 and involved in No-Go decay.},
  author={Marc Graille and Maxime Chaillet and Herman van Tilbeurgh},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 11},
  pages={7145-54}
}
The yeast protein Dom34 has been described to play a critical role in a newly identified mRNA decay pathway called No-Go decay. This pathway clears cells from mRNAs inducing translational stalls through endonucleolytic cleavage. Dom34 is related to the translation termination factor eRF1 and physically interacts with Hbs1, which is itself related to eRF3. We have solved the 2.5-A resolution crystal structure of Saccharomyces cerevisiae Dom34. This protein is organized in three domains with the… CONTINUE READING