Structure of vaccinia complement protein in complex with heparin and potential implications for complement regulation.

@article{Ganesh2004StructureOV,
  title={Structure of vaccinia complement protein in complex with heparin and potential implications for complement regulation.},
  author={Vannakambadi K. Ganesh and Scott A. Smith and Girish J. Kotwal and Krishna H. M. Murthy},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 24},
  pages={
          8924-9
        }
}
Vaccinia virus complement control protein (VCP), a homolog of the regulators of the complement activation family of proteins, inhibits complement activation through mechanisms similar to human fluid-phase complement regulators factor H and C4b-binding protein. VCP has a heparin-binding activity that assists vaccinia in host interactions. Interaction with cell-surface polyanions like heparin is centrally important in the functioning of fluid-phase complement regulators and is the basis of host… CONTINUE READING
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