Structure of urea transporters.

@article{Levin2014StructureOU,
  title={Structure of urea transporters.},
  author={Elena J. Levin and Min Zhou},
  journal={Sub-cellular biochemistry},
  year={2014},
  volume={73},
  pages={65-78}
}
Members of the urea transporter (UT) family mediate rapid, selective transport of urea down its concentration gradient. To date, crystal structures of two evolutionarily distant UTs have been solved. These structures reveal a common UT fold involving two structurally homologous domains that encircle a continuous membrane-spanning pore and indicate that UTs transport urea via a channel-like mechanism. Examination of the conserved architecture of the pore, combined with crystal structures of… CONTINUE READING