Structure of two in tandem human 17 beta-hydroxysteroid dehydrogenase genes.

  title={Structure of two in tandem human 17 beta-hydroxysteroid dehydrogenase genes.},
  author={Van Luu-The and Claude Labrie and Jacques Simard and Yves Lachance and Hai Feng Zhao and J Cou{\"e}t and G{\'e}rard Leblanc and Fernand Labrie},
  journal={Molecular endocrinology},
  volume={4 2},
Two human 17 beta-hydroxysteroid dehydrogenase (17 beta-HSD) genes (h17 beta-HSDI and h17 beta-HSDII) included in tandem within an approximately 13 kilobase pair fragment were isolated from a genomic lambda EMBL3 DNA library using cDNA encoding human 17 beta-HSD (hpE2DH216) as probe. We have determined the complete exon and intron sequences of the two genes as well as their 5' and 3'-flanking regions. Human 17 beta-HSDII contains six exons and five short introns for a total length of 3250 base… CONTINUE READING
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