Structure of transcription factor HetR required for heterocyst differentiation in cyanobacteria.

@article{Kim2011StructureOT,
  title={Structure of transcription factor HetR required for heterocyst differentiation in cyanobacteria.},
  author={Youngchang Kim and Grazyna Joachimiak and Zi Ye and T. Andrew Binkowski and Rongguang Zhang and Piotr Gornicki and Sean M. Callahan and Wolfgang R. Hess and Robert Haselkorn and Andrzej Joachimiak},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 25},
  pages={
          10109-14
        }
}
  • Youngchang Kim, Grazyna Joachimiak, +7 authors Andrzej Joachimiak
  • Published in
    Proceedings of the National…
    2011
  • Biology, Medicine
  • HetR is an essential regulator of heterocyst development in cyanobacteria. HetR binds to a DNA palindrome upstream of the hetP gene. We report the crystal structure of HetR from Fischerella at 3.0 Å. The protein is a dimer comprised of a central DNA-binding unit containing the N-terminal regions of the two subunits organized with two helix-turn-helix motifs; two globular flaps extending in opposite directions; and a hood over the central core formed from the C-terminal subdomains. The flaps and… CONTINUE READING

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