Structure of transcribing mammalian RNA polymerase II

  title={Structure of transcribing mammalian RNA polymerase II},
  author={Carrie Bernecky and Franz Herzog and Wolfgang Baumeister and J{\"u}rgen M Plitzko and Patrick Cramer},
RNA polymerase (Pol) II produces messenger RNA during transcription of protein-coding genes in all eukaryotic cells. The Pol II structure is known at high resolution from X-ray crystallography for two yeast species. Structural studies of mammalian Pol II, however, remain limited to low-resolution electron microscopy analysis of human Pol II and its complexes with various proteins. Here we report the 3.4 Å resolution cryo-electron microscopy structure of mammalian Pol II in the form of a… CONTINUE READING
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