Structure of the zinc transporter YiiP.

@article{Lu2007StructureOT,
  title={Structure of the zinc transporter YiiP.},
  author={Michael Lu and Dax Fu},
  journal={Science},
  year={2007},
  volume={317 5845},
  pages={
          1746-8
        }
}
YiiP is a membrane transporter that catalyzes Zn2+/H+ exchange across the inner membrane of Escherichia coli. Mammalian homologs of YiiP play critical roles in zinc homeostasis and cell signaling. Here, we report the x-ray structure of YiiP in complex with zinc at 3.8 angstrom resolution. YiiP is a homodimer held together in a parallel orientation through four Zn2+ ions at the interface of the cytoplasmic domains, whereas the two transmembrane domains swing out to yield a Y-shaped structure. In… CONTINUE READING

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