Structure of the zinc-binding domain of an essential component of the hepatitis C virus replicase

@article{Tellinghuisen2005StructureOT,
  title={Structure of the zinc-binding domain of an essential component of the hepatitis C virus replicase},
  author={Timothy L. Tellinghuisen and Joseph Marcotrigiano and Charles M. Rice},
  journal={Nature},
  year={2005},
  volume={435},
  pages={374-379}
}
Hepatitis C virus (HCV) is a human pathogen affecting nearly 3% of the world's population. Chronic infections can lead to cirrhosis and liver cancer. The RNA replication machine of HCV is a multi-subunit membrane-associated complex. The non-structural protein NS5A is an active component of HCV replicase, as well as a pivotal regulator of replication and a… CONTINUE READING