Structure of the yeast WD40 domain protein Cia1, a component acting late in iron-sulfur protein biogenesis.

@article{Srinivasan2007StructureOT,
  title={Structure of the yeast WD40 domain protein Cia1, a component acting late in iron-sulfur protein biogenesis.},
  author={Vasundara Srinivasan and Daili J. A. Netz and Holger Webert and Judita Mascarenhas and Antonio J Pierik and Hartmut Michel and Roland Lill},
  journal={Structure},
  year={2007},
  volume={15 10},
  pages={
          1246-57
        }
}
The WD40-repeat protein Cia1 is an essential, conserved member of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery in eukaryotes. Here, we report the crystal structure of Saccharomyces cerevisiae Cia1 to 1.7 A resolution. The structure folds into a beta propeller with seven blades pseudo symmetrically arranged around a central axis. Structure-based sequence alignment of Cia1 proteins shows that the WD40 propeller core elements are highly conserved. Site-directed mutagenesis of… CONTINUE READING

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