Structure of the winged-helix protein hRFX1 reveals a new mode of DNA binding

@article{Gajiwala2000StructureOT,
  title={Structure of the winged-helix protein hRFX1 reveals a new mode of DNA binding},
  author={Ketan S. Gajiwala and Hua Chen and F. Cornille and B. Roques and Walter Reith and Bernard Mach and Stephen K. Burley},
  journal={Nature},
  year={2000},
  volume={403},
  pages={916-921}
}
Regulatory factor X (RFX) proteins are transcriptional activators that recognize X-boxes (DNA of the sequence 5′-GTNRCC(0–3N)RGYAAC-3′, where N is any nucleotide, R is a purine and Y is a pyrimidine) using a highly conserved 76-residue DNA-binding domain (DBD). DNA-binding defects in the protein RFX5 cause bare lymphocyte syndrome or major histocompatibility antigen class II deficiency. RFX1, -2 and -3 regulate expression of other medically important gene products (for example, interleukin-5… CONTINUE READING
79 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 79 extracted citations

Similar Papers

Loading similar papers…