Structure of the universal stress protein of Haemophilus influenzae.

  title={Structure of the universal stress protein of Haemophilus influenzae.},
  author={Marcelo C Sousa and David B. McKay},
  volume={9 12},
BACKGROUND The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced several-fold when cellular viability is challenged with heat shock, nutrient starvation, stress agents which arrest cell growth, or DNA-damaging agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, suggesting that it asserts a general "stress endurance" activity. However, neither the structure of UspA nor the biochemical mechanism by which… CONTINUE READING


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