Structure of the tropomyosin overlap complex from chicken smooth muscle: insight into the diversity of N-terminal recognition.

@article{Frye2010StructureOT,
  title={Structure of the tropomyosin overlap complex from chicken smooth muscle: insight into the diversity of N-terminal recognition.},
  author={Jeremiah J. Frye and Vadim A. Klenchin and Ivan Rayment},
  journal={Biochemistry},
  year={2010},
  volume={49 23},
  pages={
          4908-20
        }
}
Tropomyosin is a stereotypical alpha-helical coiled coil that polymerizes to form a filamentous macromolecular assembly that lies on the surface of F-actin. The interaction between the C-terminal and N-terminal segments on adjacent molecules is known as the overlap region. We report here two X-ray structures of the chicken smooth muscle tropomyosin overlap complex. A novel approach was used to stabilize the C-terminal and N-terminal fragments. Globular domains from both the human DNA ligase… CONTINUE READING
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