Structure of the streptococcal cell wall C5a peptidase.

@article{Brown2005StructureOT,
  title={Structure of the streptococcal cell wall C5a peptidase.},
  author={Christopher K L Brown and Z. Y. Gu and Yury V. Matsuka and Sai Sudha Purushothaman and Laurie A. Winter and Patrick P. Cleary and Stephen B. Olmsted and Douglas H. Ohlendorf and Cathleen A. Earhart},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 51},
  pages={
          18391-6
        }
}
  • Christopher K L Brown, Z. Y. Gu, +6 authors Cathleen A. Earhart
  • Published in
    Proceedings of the National…
    2005
  • Biology, Medicine
  • The structure of a cell surface enzyme from a gram-positive pathogen has been determined to 2-A resolution. Gram-positive pathogens have a thick cell wall to which proteins and carbohydrate are covalently attached. Streptococcal C5a peptidase (SCP), is a highly specific protease and adhesin/invasin. Structural analysis of a 949-residue fragment of the [D130A,S512A] mutant of SCP from group B Streptococcus (S. agalactiae, SCPB) revealed SCPB is composed of five distinct domains. The N-terminal… CONTINUE READING

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