Structure of the spliceosomal U4 snRNP core domain and its implication for snRNP biogenesis

@inproceedings{Leung2011StructureOT,
  title={Structure of the spliceosomal U4 snRNP core domain and its implication for snRNP biogenesis},
  author={Adelaine K.-W. Leung and Kiyoshi Nagai and Jade Li},
  booktitle={Nature},
  year={2011}
}
The spliceosome is a dynamic macromolecular machine that assembles on pre-messenger RNA substrates and catalyses the excision of non-coding intervening sequences (introns). Four of the five major components of the spliceosome, U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), contain seven Sm proteins (SmB/B′, SmD1, SmD2, SmD3, SmE, SmF and SmG… CONTINUE READING