Structure of the single stable hemoglobin adduct formed by 4-aminobiphenyl in vivo.

  title={Structure of the single stable hemoglobin adduct formed by 4-aminobiphenyl in vivo.},
  author={Dagmar Ringe and Robert J Turesky and Paul L. Skipper and Steven R Tannenbaum},
  journal={Chemical research in toxicology},
  volume={1 1},
Sir: Aromatic amines are a class of environmental contaminants capable of producing a variety of toxic effects including carcinogenesis and methemoglobinemia (1-6). These two end points are often effected by a common metabolic intermediate, the N-hydroxylamine. Carcinogenesis is thought to be initiated by the reaction of the electrophilic N-hydroxyamine or a conjugate thereof with DNA (4-6). In the red blood cell, the N-hydroxylamine reacts with oxyhemoglobin through a process in which the… CONTINUE READING


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