Structure of the single stable hemoglobin adduct formed by 4-aminobiphenyl in vivo.

@article{Ringe1988StructureOT,
  title={Structure of the single stable hemoglobin adduct formed by 4-aminobiphenyl in vivo.},
  author={Dagmar Ringe and Robert J Turesky and Paul L. Skipper and Steven R Tannenbaum},
  journal={Chemical research in toxicology},
  year={1988},
  volume={1 1},
  pages={22-4}
}
Sir: Aromatic amines are a class of environmental contaminants capable of producing a variety of toxic effects including carcinogenesis and methemoglobinemia (1-6). These two end points are often effected by a common metabolic intermediate, the N-hydroxylamine. Carcinogenesis is thought to be initiated by the reaction of the electrophilic N-hydroxyamine or a conjugate thereof with DNA (4-6). In the red blood cell, the N-hydroxylamine reacts with oxyhemoglobin through a process in which the… CONTINUE READING

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References

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Showing 1-10 of 33 references

On the mechanism of reactions of nitrosoarenes with thiols. Formation of a common intermediate ‘semimcrcapital”

  • H. Klehr, P. Eyre, W. Schafer
  • Biol. Chem. Hopper-Seyler
  • 1985

In uiuo dosimetry

  • L. C. Green, P. L. Skipper, R. J. Turesky, M. S. Bryant, S. R. Tannenbaum
  • 1984

IARC Monogr . Eual . Carcinog

  • D. B. Clayson
  • Natl . Cancer Inst . Mongr .
  • 1981

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