Structure of the segmentation gene paired and the Drosophila PRD gene set as part of a gene network

@article{Frigerio1986StructureOT,
  title={Structure of the segmentation gene paired and the Drosophila PRD gene set as part of a gene network},
  author={Gabriella Frigerio and Maya Burri and Daniel Bopp and Stefan Baumgartner and Markus Noll},
  journal={Cell},
  year={1986},
  volume={47},
  pages={735-746}
}
The sequence of paired, a pair-rule gene required for segmentation in Drosophila, is presented. A search for genes with domains homologous to the paired gene was initiated and three homologues from a set of 12 were characterized with respect to temporal or spatial expression and sequence homologies. All four are transcribed in early development, one in the oocyte and during cleavage stages in the form of a gradient. In addition to the prd-specific his-pro repeat, some of the 12 genes contain M… 
Conservation of a large protein domain in the segmentation gene paired and in functionally related genes of Drosophila
TLDR
Together with the PRD repeat, the Drosophila paired gene contains at least three different domains, each defining a gene set thought to be important for development.
Multiple regulatory elements direct the complex expression pattern of the Drosophila segmentation gene paired
TLDR
It is proposed that regulation of prd by pair-rule and gap gene products is mediated by upstream and downstream cis-regulatory elements.
The segmentation and homeotic gene network in early Drosophila development
TLDR
Some of the central issues and ideas in this field are discussed, not to provide a comprehensive review of all that is known, but several important features about the segmentation and homeotic gene network are revealed.
Murine genes with homology to Drosophila segmentation genes.
As a potential method to define genes that control vertebrate segmentation processes during embryogenesis, murine genes containing a protein domain homologous to the Drosophila paired box sequence
Divergent homeo box proteins recognize similar DNA sequences in Drosophila
A member of a small group of genes in Drosophila that define the segmentation pattern of the early embryo1–5 even-skipped (eve), which plays a key role in a network of interactions among segmentation
Gap gene properties of the pair-rule gene runt during Drosophila segmentation.
TLDR
Genetic experiments demonstrated that regulation of gap gene expression by runt is a normal component of the regulatory program that generates the segmented body pattern of the Drosophila embryo.
Network of interactions among pair-rule genes regulating paired expression during primordial segmentation of Drosophila
TLDR
A two-step conversion of the initial analogue specification of position along the anteroposterior axis into a digital code specified by combinations of active segment-polarity and homeotic genes is discussed.
The interaction of proteins encoded by Drosophila homeotic and segmentation genes with specific DNA sequences.
TLDR
It is shown that the homeodomains encoded by two of the ANT-C loci confer sequence-specific DNA-binding activity, supported by the finding that a temperature-sensitive ftz mutation that causes a pairwise fusion of embryonic segments also reduces the affinity of the ftzHomeodomain for DNA.
Homeo box genes and animal development
TLDR
Comparison of specific Drosophila and mouse gene homeo box gene sequences shows that some of the individual genes in the two species are truly homologues in terms of structure, i.e., individualHomeo box genes had evolved conserved and separate functions before the evolutionary divergence that eventually gave rise to arthropods and mammals.
Segmentation in Drosophila
TLDR
The Drosophila egg contains three determinants produced and localized by maternal effect genes that form gradients during early zygotic development and are responsible for segmenting the anterior, posterior, and terminal parts of the body.
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References

SHOWING 1-10 OF 47 REFERENCES
Conservation of a large protein domain in the segmentation gene paired and in functionally related genes of Drosophila
TLDR
Together with the PRD repeat, the Drosophila paired gene contains at least three different domains, each defining a gene set thought to be important for development.
A homologous protein-coding sequence in drosophila homeotic genes and its conservation in other metazoans
TLDR
It is shown that this DNA homology (the homeo box) is due to a conserved protein-coding sequence present in these three pattern-formation genes and is reflected in a structural homology in their gene products.
Structural organization and sequence of the homeotic gene Antennapedia of Drosophila melanogaster.
TLDR
The structure of the Drosophila melanogaster Antennapedia (Antp) gene has been investigated by the isolation and sequencing of different cDNAs and genomic clones to reveal a complex and unusual gene structure.
Sequence of a Drosophila segmentation gene: protein structure homology with DNA-binding proteins
TLDR
Mutations in the fushi tarazu (ftz) locus of Drosophila result in embryos with half the usual number of body segments, and a portion of the conserved protein domain present in ftz and several homoeotic genes resembles the DNA- binding region of prokaryotic DNA-binding proteins.
Isolation of a homoeo box-containing gene from the engrailed region of Drosophila and the spatial distribution of its transcripts
TLDR
It is reported that like many of the homoeotic genes of the bithorax and Antennapedia complexes, engrailed has a ‘homoeo box’ sequence; also, like the segmentation gene fushi tarazu, the engrailing gene displays a periodic pattern of expression in Drosophila embryos.
Transcription pattern of the Drosophila segmentation gene hairy
TLDR
It is found that transcripts of one pair-rule gene, hairy, accumulate in eight distinct regions of the early embryo, and this pattern of expression is compared with that of another pair- rule gene, fushi tarazu, and its dependence on maternally expressed genes is described.
opa: A novel family of transcribed repeats shared by the Notch locus and other developmentally regulated loci in D. melanogaster
TLDR
Evidence is presented indicating that the Notch repeat is a member of a novel family of repetitive elements, which is term the opa family, and the data suggest that some of these elements may be not only transcribed but also translated.
The engrailed locus of drosophila: Structural analysis of an embryonic transcript
TLDR
It is shown that a neighboring gene has a large region with strong homology to engrailed, and that it also contains a homeo box, which is located near the 3' end of a 1700 bp open reading frame.
Spatial distribution of transcripts from the segmentation gene fushi tarazu during Drosophila embryonic development
TLDR
The results suggest that the ftz+ gene plays a key role in the determination of the segmentation pattern in the embryo.
The molecular organization of the Antennapedia locus of drosophila
The Antennapedia complex (ANT-C) of Drosophila is a cluster of genes involved in the regulation of morphogenesis, including at least three homoeotic loci (Antp, Scr, and pb), in which mutations cause
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