Structure of the second Single Stranded DNA Binding protein (SSBb) from Mycobacterium smegmatis.

@article{Singh2016StructureOT,
  title={Structure of the second Single Stranded DNA Binding protein (SSBb) from Mycobacterium smegmatis.},
  author={Amandeep Singh and Umesh Varshney and Magesh Vijayan},
  journal={Journal of structural biology},
  year={2016},
  volume={196 3},
  pages={448-454}
}
All mycobacteria with sequenced genomes, except M. leprae, have a second Single Stranded DNA Binding protein (SSBb) in addition to the canonical one (SSBa). This paralogue from M. smegmatis (MsSSBb) has been cloned, expressed and purified. The protein, which is probably involved in stress response, has been crystallized and X-ray analyzed in the first structure elucidation of a mycobacterial SSBb. In spite of the low sequence identity between SSBas and SSBbs in mycobacteria, the tertiary and… CONTINUE READING
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