Structure of the retinoid X receptor α–liver X receptor β (RXRα–LXRβ) heterodimer on DNA

@article{Lou2014StructureOT,
  title={Structure of the retinoid X receptor $\alpha$–liver X receptor $\beta$ (RXR$\alpha$–LXR$\beta$) heterodimer on DNA},
  author={Xiaohua Lou and G. Toresson and C. Benod and J. Suh and Kevin J Philips and P. Webb and J. Gustafsson},
  journal={Nature Structural \&Molecular Biology},
  year={2014},
  volume={21},
  pages={277-281}
}
Nuclear receptors (NRs) are conditional transcription factors with common multidomain organization that bind diverse DNA elements. How DNA sequences influence NR conformation is poorly understood. Here we report the crystal structure of the human retinoid X receptor α–liver X receptor β (RXRα–LXRβ) heterodimer on its cognate element, an AGGTCA direct repeat spaced by 4 nt. The complex has an extended X-shaped arrangement, with DNA- and ligand-binding domains crossed, in contrast to the parallel… Expand
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Common architecture of nuclear receptor heterodimers on DNA direct repeat elements with different spacings
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