Structure of the retinoblastoma tumour-suppressor pocket domain bound to a peptide from HPV E7

@article{Lee1998StructureOT,
  title={Structure of the retinoblastoma tumour-suppressor pocket domain bound to a peptide from HPV E7},
  author={J Lee and Alicia A. Russo and Nikola P. Pavletich},
  journal={Nature},
  year={1998},
  volume={391},
  pages={859-865}
}
The pocket domain of the retinoblastoma (Rb) tumour suppressor is central to Rb function, and is frequently inactivated by the binding of the human papilloma virus E7 oncoprotein in cervical cancer. The crystal structure of the Rb pocket bound to a nine-residue E7 peptide containing the LxCxE motif, shared by other Rb-binding viral and cellular proteins, shows that the LxCxE peptide binds a highly conserved groove on the B-box portion of the pocket; the A-box portion appears to be required for… CONTINUE READING
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