Structure of the neutrophil-activating protein from Helicobacter pylori.

  title={Structure of the neutrophil-activating protein from Helicobacter pylori.},
  author={Giuseppe Zanotti and Elena Papinutto and William G Dundon and Roberto Battistutta and Michela Seveso and Giuseppe Giudice and Rino Rappuoli and Cesare Montecucco},
  journal={Journal of molecular biology},
  volume={323 1},
Helicobacter pylori is a major human pathogen associated with severe gastroduodenal diseases, including ulcers and cancers. An H.pylori protein that is highly immunogenic in humans and mice has been identified recently. This protein has been termed HP-NAP, due to its ability of activating neutrophils. In order to achieve a molecular understanding of its unique immunogenic and pro-inflammatory properties, we have determined its three-dimensional structure. Its quaternary structure is similar to… CONTINUE READING


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