Structure of the mouse tyrosine hydroxylase gene.

  title={Structure of the mouse tyrosine hydroxylase gene.},
  author={Nakao Iwata and Koh Kobayashi and Toshiyasu Sasaoka and Hirokazu Hidaka and Toshiharu Toshi Nagatsu},
  journal={Biochemical and biophysical research communications},
  volume={182 1},
The mouse tyrosine hydroxylase (TH) gene was isolated from a genomic library by cross-hybridization with human TH cDNA probe. Nucleotide sequence analysis of two overlapping genomic clones showed that this gene is split into 13 exons distributed about 7.5 kb in length. The transcription initiation site was determined by primer extension analysis with mouse adrenal gland poly(A)+RNA. The structure of the mouse TH gene was similar to that of the human TH gene, but it contained neither the… CONTINUE READING
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