Structure of the mitotic checkpoint complex

  title={Structure of the mitotic checkpoint complex},
  author={William Chong Hang Chao and Kiran Kulkarni and Ziguo Zhang and Eric Kong and David Barford},
In mitosis, the spindle assembly checkpoint (SAC) ensures genome stability by delaying chromosome segregation until all sister chromatids have achieved bipolar attachment to the mitotic spindle. The SAC is imposed by the mitotic checkpoint complex (MCC), whose assembly is catalysed by unattached chromosomes and which binds and inhibits the anaphase-promoting complex/cyclosome (APC/C), the E3 ubiquitin ligase that initiates chromosome segregation. Here, using the crystal structure of… CONTINUE READING
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