Structure of the membrane domain of respiratory complex I

  title={Structure of the membrane domain of respiratory complex I},
  author={Rouslan Efremov and Leonid A. Sazanov},
Complex I is the first and largest enzyme of the respiratory chain, coupling electron transfer between NADH and ubiquinone to the translocation of four protons across the membrane. It has a central role in cellular energy production and has been implicated in many human neurodegenerative diseases. The L-shaped enzyme consists of hydrophilic and membrane domains. Previously, we determined the structure of the hydrophilic domain. Here we report the crystal structure of the Esherichia coli complex… CONTINUE READING
Highly Influential
This paper has highly influenced 18 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Recent Discussions
This paper has been referenced on Twitter 10 times over the past 90 days. VIEW TWEETS
102 Extracted Citations
65 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 102 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 65 references

The role of subunit NuoL for proton translocation by the respiratory complex I

  • S Steimle
  • Biochemistry 50,
  • 2011

MolProbity : allatom structure validation for macromolecular crystallography

  • V. B. Chen
  • Acta Crystallogr . D
  • 2010

Similar Papers

Loading similar papers…