Structure of the mediator head module bound to the carboxy-terminal domain of RNA polymerase II.

@article{Robinson2012StructureOT,
  title={Structure of the mediator head module bound to the carboxy-terminal domain of RNA polymerase II.},
  author={Philip J Robinson and David A. Bushnell and Michael J Trnka and Alma L. Burlingame and Roger D. Kornberg},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 44},
  pages={
          17931-5
        }
}
The X-ray crystal structure of the Head module, one-third of the Mediator of transcriptional regulation, has been determined as a complex with the C-terminal domain (CTD) of RNA polymerase II. The structure reveals multiple points of interaction with an extended conformation of the CTD; it suggests a basis for regulation by phosphorylation of the CTD. Biochemical studies show a requirement for Mediator-CTD interaction for transcription. 

Citations

Publications citing this paper.
SHOWING 1-10 OF 49 CITATIONS

Role for the MED21-MED7 Hinge in Assembly of the Mediator-RNA Polymerase II Holoenzyme.

  • The Journal of biological chemistry
  • 2016
VIEW 18 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Molecular architecture of the yeast Mediator complex

VIEW 19 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

Structure of a Complete Mediator-RNA Polymerase II Pre-Initiation Complex

VIEW 10 EXCERPTS
CITES METHODS & BACKGROUND
HIGHLY INFLUENCED

The Mediator complex and transcription regulation

  • Critical reviews in biochemistry and molecular biology
  • 2013
VIEW 8 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 38 REFERENCES

Architecture of the Mediator head module

T Imasaki
  • Nature
  • 2011
VIEW 1 EXCERPT

Structure of an RNA polymerase II - TFIIB complex and the transcription initiation mechanism

DA Bushnell, P Cramer, RD Kornberg
  • Science
  • 2010

Similar Papers