Structure of the mammalian oligosaccharyl-transferase complex in the native ER protein translocon.

@article{Pfeffer2014StructureOT,
  title={Structure of the mammalian oligosaccharyl-transferase complex in the native ER protein translocon.},
  author={Stefan Pfeffer and Johanna Dudek and Marko Gogala and Stefan Schorr and Johannes Linxweiler and Sven Lang and Thomas Becker and Roland Beckmann and Richard Zimmermann and Friedrich F{\"o}rster},
  journal={Nature communications},
  year={2014},
  volume={5},
  pages={3072}
}
In mammalian cells, proteins are typically translocated across the endoplasmic reticulum (ER) membrane in a co-translational mode by the ER protein translocon, comprising the protein-conducting channel Sec61 and additional complexes involved in nascent chain processing and translocation. As an integral component of the translocon, the oligosaccharyl-transferase complex (OST) catalyses co-translational N-glycosylation, one of the most common protein modifications in eukaryotic cells. Here we use… CONTINUE READING