Structure of the l(2)gl gene of Drosophila and delimitation of its tumor suppressor domain.

@article{Jacob1987StructureOT,
  title={Structure of the l(2)gl gene of Drosophila and delimitation of its tumor suppressor domain.},
  author={Lutz Jacob and M Opper and B Metzroth and Bounpheng Phannavong and Bernard M. Mechler},
  journal={Cell},
  year={1987},
  volume={50 2},
  pages={215-25}
}
We have previously cloned lethal(2)giant larvae, a tumor-suppressor gene of Drosophila that normally controls cell proliferation and/or differentiation in the optic centers of the brain and the imaginal discs. Here we describe the structure of the l(2)gl genes as determined by sequencing genomic and cDNA clones. The structure of the cDNAs indicates the use of alternative splicing, either in the 5' untranslated exons or in the 3' coding exons. Thus the gene encodes two putative proteins of 1161… CONTINUE READING

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