Structure of the integrin binding fragment from fibrillin-1 gives new insights into microfibril organization.

@article{Lee2004StructureOT,
  title={Structure of the integrin binding fragment from fibrillin-1 gives new insights into microfibril organization.},
  author={Stephen S J Lee and Vroni Knott and Jelena Jovanovi{\'c} and Karl Harlos and Jonathan M Grimes and Laurence Choulier and Helen J. Mardon and David I Stuart and Penny A Handford},
  journal={Structure},
  year={2004},
  volume={12 4},
  pages={717-29}
}
Human fibrillin-1, the major structural protein of extracellular matrix (ECM) 10-12 nm microfibrils, is dominated by 43 calcium binding epidermal growth factor-like (cbEGF) and 7 transforming growth factor beta binding protein-like (TB) domains. Crystal structures reveal the integrin binding cbEGF22-TB4-cbEGF23 fragment of human fibrillin-1 to be a Ca(2+)-rigidified tetragonal pyramid. We suggest that other cbEGF-TB pairs within the fibrillins may adopt a similar orientation to cbEGF22-TB4. In… CONTINUE READING
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