Structure of the intact PPAR-γ–RXR-α nuclear receptor complex on DNA

@article{Chandra2008StructureOT,
  title={Structure of the intact PPAR-$\gamma$–RXR-$\alpha$ nuclear receptor complex on DNA},
  author={V. Chandra and P. Huang and Y. Hamuro and S. Raghuram and Yongjun Wang and T. Burris and F. Rastinejad},
  journal={Nature},
  year={2008},
  volume={456},
  pages={350-356}
}
Nuclear receptors are multi-domain transcription factors that bind to DNA elements from which they regulate gene expression. The peroxisome proliferator-activated receptors (PPARs) form heterodimers with the retinoid X receptor (RXR), and PPAR-γ has been intensively studied as a drug target because of its link to insulin sensitization. Previous structural studies have focused on isolated DNA or ligand-binding segments, with no demonstration of how multiple domains cooperate to modulate receptor… Expand
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