Structure of the insulin receptor of the cultured human lymphoblastoid cell IM-9. Evidence suggesting that two subunits are required for insulin binding.

Abstract

We have studied the binding unit of the high affinity insulin receptor from the plasma membrane of the cultured human lymphoblastoid cell IM-9, solubilized with the nonionic detergent Triton X-100. We have previously shown this receptor to be an M, 310,000 protein associated with approximately 0.5 g of detergent per g of protein. High energy irradiation of… (More)

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