Structure of the insulin receptor ectodomain reveals a folded-over conformation

@article{Mckern2006StructureOT,
  title={Structure of the insulin receptor ectodomain reveals a folded-over conformation},
  author={N. Mckern and M. Lawrence and V. Streltsov and M. Lou and T. Adams and G. Lovrecz and T. Elleman and K. Richards and J. Bentley and P. Pilling and P. Hoyne and K. Cartledge and Tam M. Pham and J. L. Lewis and S. E. Sankovich and V. Stoichevska and E. D. Silva and C. Robinson and M. Frenkel and L. Sparrow and R. T. Fernley and V. Epa and C. Ward},
  journal={Nature},
  year={2006},
  volume={443},
  pages={218-221}
}
The insulin receptor is a phylogenetically ancient tyrosine kinase receptor found in organisms as primitive as cnidarians and insects. In higher organisms it is essential for glucose homeostasis, whereas the closely related insulin-like growth factor receptor (IGF-1R) is involved in normal growth and development. The insulin receptor is expressed in two isoforms, IR-A and IR-B; the former also functions as a high-affinity receptor for IGF-II and is implicated, along with IGF-1R, in malignant… Expand
247 Citations
The signalling conformation of the insulin receptor ectodomain
  • 25
  • PDF
Structural and Biological Properties of the Drosophila Insulin-like Peptide 5 Show Evolutionary Conservation*
  • 48
  • PDF
The dimeric ectodomain of the alkali-sensing insulin receptor–related receptor (ectoIRR) has a droplike shape
  • 3
  • PDF
Visualization of ligand-induced transmembrane signaling in the full-length human insulin receptor
  • 43
  • Highly Influenced
  • PDF
Insulin receptor structure and its implications for the IGF-1 receptor.
  • 141
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 35 REFERENCES
Three-dimensional Structural Interactions of Insulin and Its Receptor*
  • 50
  • PDF
Structural organization of the human insulin receptor ectodomain.
  • 51
Single-molecule imaging of human insulin receptor ectodomain and its Fab complexes.
  • 38
The insulin receptor: from protein sequence to structure.
  • 33
  • PDF
...
1
2
3
4
...