Structure of the inositol-1-phosphate cytidylyltransferase from Thermotoga maritima.

@article{Kurnasov2013StructureOT,
  title={Structure of the inositol-1-phosphate cytidylyltransferase from Thermotoga maritima.},
  author={Oleg V. Kurnasov and Hung-Jie Daniel Luk and Mary Fedarko Roberts and Boguslaw Stec},
  journal={Acta crystallographica. Section D, Biological crystallography},
  year={2013},
  volume={69 Pt 9},
  pages={
          1808-17
        }
}
The unique steps in the synthesis of an unusual osmolyte in hyperthermophiles, di-myo-inositol-1,1'-phosphate (DIP), involve the production of CDP-inositol and its condensation with an inositol-1-phosphate molecule to form phosphorylated DIP. While many organisms fuse both activities into a single enzyme, the two are separate in Thermotoga maritima. The crystal structure of the T. maritima inositol-1-phosphate cytidylyltransferase, which as a soluble protein may transiently associate with its… CONTINUE READING