Structure of the human telomere in Na+ solution: an antiparallel (2+2) G-quadruplex scaffold reveals additional diversity

@inproceedings{Lim2013StructureOT,
  title={Structure of the human telomere in Na+ solution: an antiparallel (2+2) G-quadruplex scaffold reveals additional diversity},
  author={Kah Wai Lim and Veronica Chinn Min Ng and Nerea Mart{\'i}n-Pintado and Brahim Heddi and Anh Tu{\^a}n Phan},
  booktitle={Nucleic acids research},
  year={2013}
}
Single-stranded DNA overhangs at the ends of human telomeric repeats are capable of adopting four-stranded G-quadruplex structures, which could serve as potential anticancer targets. Out of the five reported intramolecular human telomeric G-quadruplex structures, four were formed in the presence of K(+) ions and only one in the presence of Na(+) ions, leading often to a perception that this structural polymorphism occurs exclusively in the presence of K(+) but not Na(+). Here we present the… CONTINUE READING
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