Structure of the human paralemmin gene (PALM), mapping to human chromosome 19p13.3 and mouse chromosome 10, and exclusion of coding mutations in grizzled, mocha, jittery, and hesitant mice.

@article{Burwinkel1998StructureOT,
  title={Structure of the human paralemmin gene (PALM), mapping to human chromosome 19p13.3 and mouse chromosome 10, and exclusion of coding mutations in grizzled, mocha, jittery, and hesitant mice.},
  author={Barbara Burwinkel and G Miglierini and Dieter E. Jenne and Debra J. Gilbert and Neal G. Copeland and Nancy A. Jenkins and H. Z. Ring and Uta Francke and Manfred W Kilimann},
  journal={Genomics},
  year={1998},
  volume={49 3},
  pages={462-6}
}
Paralemmin is a newly identified protein that is associated with the plasma membrane and with intracellular membranes through a lipid anchor. It is abundant in brain, is expressed at intermediate levels in the kidney and in endocrine cells, and occurs at low levels in many other tissues. As it is a candidate for genetic disorders that affect membrane functions, we have determined the structure of the human paralemmin gene, PALM, showing that it is organized into nine exons. Moreover, we have… CONTINUE READING