Structure of the human mitochondrial monoamine oxidase B: new chemical implications for neuroprotectant drug design.

Abstract

Monoamine oxidase B (MAO-B) is an outer mitochondrial membrane-bound flavoenzyme that is a well-known target for antidepressant and neuroprotective drugs. The 3A resolution structure of recombinant human MAO-B originally determined was of the enzyme complexed with pargyline, an irreversible inhibitor covalently bound to the N5 atom of the flavin coenzyme… (More)

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@article{Binda2006StructureOT, title={Structure of the human mitochondrial monoamine oxidase B: new chemical implications for neuroprotectant drug design.}, author={Claudia Binda and Franti{\vs}ek Hub{\'a}lek and M. Li and Neal Castagnoli and Dale E. Edmondson and Andrea Mattevi}, journal={Neurology}, year={2006}, volume={67 7 Suppl 2}, pages={S5-7} }