Structure of the human glucagon class B G-protein-coupled receptor

  title={Structure of the human glucagon class B G-protein-coupled receptor},
  author={Fai Siu and Min He and Chris de Graaf and Gye Won Han and Dehua Yang and Zhiyun Zhang and Caihong Zhou and Qingping Xu and Daniel Wacker and Jeremiah S. Joseph and Wei Liu and Jesper F Lau and Vadim Cherezov and Vsevolod Katritch and Ming-wei Wang and Raymond C. Stevens},
Binding of the glucagon peptide to the glucagon receptor (GCGR) triggers the release of glucose from the liver during fasting; thus GCGR plays an important role in glucose homeostasis. Here we report the crystal structure of the seven transmembrane helical domain of human GCGR at 3.4 Å resolution, complemented by extensive site-specific mutagenesis, and a hybrid model of glucagon bound to GCGR to understand the molecular recognition of the receptor for its native ligand. Beyond the shared seven… CONTINUE READING
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