Structure of the human glucagon class B G-protein-coupled receptor

@article{Siu2013StructureOT,
  title={Structure of the human glucagon class B G-protein-coupled receptor},
  author={Fai Yiu Siu and Min He and Chris de Graaf and Gye Won Han and Dehua Yang and Zhiyun Zhang and Caihong Zhou and Qingping Xu and Daniel Wacker and Jeremiah S. Joseph and Wei Liu and Jesper Lau and Vadim Cherezov and Vsevolod Katritch and Ming-wei Wang and Raymond C. Stevens},
  journal={Nature},
  year={2013},
  volume={499},
  pages={444-449}
}
  • Fai Yiu Siu, Min He, +13 authors Raymond C. Stevens
  • Published 2013
  • Biology, Medicine
  • Nature
  • Binding of the glucagon peptide to the glucagon receptor (GCGR) triggers the release of glucose from the liver during fasting; thus GCGR plays an important role in glucose homeostasis. [...] Key Result Beyond the shared seven transmembrane fold, the GCGR transmembrane domain deviates from class A G-protein-coupled receptors with a large ligand-binding pocket and the first transmembrane helix having a ‘stalk’ region that extends three alpha-helical turns above the plane of the membrane.Expand Abstract

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    Molecular basis for negative regulation of the glucagon receptor