Structure of the human dimeric ATM kinase

  title={Structure of the human dimeric ATM kinase},
  author={Wilson C. Y. Lau and Yinyin Li and Zhe Liu and Yuanzhu Gao and Qinfen Zhang and Michael S. Y. Huen},
  booktitle={Cell cycle},
DNA-double strand breaks activate the serine/threonine protein kinase ataxia-telangiectasia mutated (ATM) to initiate DNA damage signal transduction. This activation process involves autophosphorylation and dissociation of inert ATM dimers into monomers that are catalytically active. Using single-particle electron microscopy (EM), we determined the structure of dimeric ATM in its resting state. The EM map could accommodate the crystal structure of the N-terminal truncated mammalian target of… CONTINUE READING
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