Structure of the human RECQ1 helicase reveals a putative strand-separation pin.

  title={Structure of the human RECQ1 helicase reveals a putative strand-separation pin.},
  author={Ashley C W Pike and Binesh Shrestha and Venkateswarlu Popuri and Nicola A. Burgess-Brown and Laura Muzzolini and Silvia Costantini and Alessandro Vindigni and Opher Gileadi},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={106 4},
RecQ-like helicases, which include 5 members in the human genome, are important in maintaining genome integrity. We present a crystal structure of a truncated form of the human RECQ1 protein with Mg-ADP. The truncated protein is active in DNA fork unwinding but lacks other activities of the full-length enzyme: disruption of Holliday junctions and DNA strand annealing. The structure of human RECQ1 resembles that of Escherichia coli RecQ, with some important differences. All structural domains… CONTINUE READING
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