Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain.

@article{Popowicz2008StructureOT,
  title={Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain.},
  author={G M Popowicz and Anna Czarna and Tad A. Holak},
  journal={Cell cycle},
  year={2008},
  volume={7 15},
  pages={2441-3}
}
The Mdmx oncoprotein has only recently emerged as a critical-independent to Mdm2-regulator of p53 activation. We have determined the crystal structure of the N-terminal domain of human Mdmx bound to a 15-residue transactivation domain peptide of human p53. The structure shows why antagonists of the Mdm2 binding to p53 are ineffective in the Mdmx-p53 interaction. 

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