Structure of the herpesvirus major capsid protein.

  title={Structure of the herpesvirus major capsid protein.},
  author={Brian Bowman and Matthew L. Baker and Frazer J. Rixon and Wah Chiu and Florante A. Quiocho},
  journal={The EMBO journal},
  volume={22 4},
Herpes simplex virus-1 (HSV-1) virions are large, complex enveloped particles containing a proteinaceous tegument layer connected to an icosahedral capsid. The major capsid protein, VP5 (149 kDa), makes up both types of capsomere, pentons and hexons. Limited trypsin digestion of VP5 identified a single stable 65 kDa fragment which represents a proposed… CONTINUE READING