Structure of the hepatic control region of the human apolipoprotein E/C-I gene locus.

@article{Dang1995StructureOT,
  title={Structure of the hepatic control region of the human apolipoprotein E/C-I gene locus.},
  author={Quyen Dang and Don K Walker and Stacy Taylor and Christian Allan and Peggy Chin and Jun Fan and Jena Taylor},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 38},
  pages={22577-85}
}
The specificity of expression in the liver of the human apolipoprotein (apo) E/C-I gene locus is determined by a hepatic control region (HCR) that is located 15 kilobases downstream of the apoE gene. DNase I footprint studies of this sequence using nuclear extracts identified a region of the HCR that is enriched in nuclear protein-binding sites. Nuclease analysis of chromatin revealed liver-specific DNase I-hypersensitive sites that were associated with this region, and additional liver… CONTINUE READING