Structure of the has operon promoter and regulation of hyaluronic acid capsule expression in group A Streptococcus.

@article{Albert1998StructureOT,
  title={Structure of the has operon promoter and regulation of hyaluronic acid capsule expression in group A Streptococcus.},
  author={Sebasti{\'a}n Albert{\'i} and Cameron D. Ashbaugh and Michael R. Wessels},
  journal={Molecular microbiology},
  year={1998},
  volume={28 2},
  pages={343-53}
}
Group A streptococcal strains vary widely in the amount of hyaluronic acid capsule they produce, although the has operon, which encodes the enzymes required for hyaluronic acid synthesis, is highly conserved. The three genes making up the has operon are transcribed from a single promoter located upstream of the first gene in the operon, hasA. To investigate transcriptional regulation of capsule synthesis, we studied the structure and function of the has operon promoter sequences from two… CONTINUE READING

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