Structure of the gene of tum- transplantation antigen P198: a point mutation generates a new antigenic peptide

  title={Structure of the gene of tum- transplantation antigen P198: a point mutation generates a new antigenic peptide},
  author={Catherine Sibille and Patrick Chomez and Claude Wildmann and Aline Van Pel and Etienne De Plaen and Janet L. Maryanski and V de Bergeyck and T. Boon},
  journal={The Journal of Experimental Medicine},
  pages={35 - 45}
Mutagen treatment of mouse tumor cell line P815 produces tum- variants that are rejected by syngeneic mice because they express new transplantation antigens. These tum- antigens are recognized by cytotoxic T lymphocytes (CTL) but induce no detectable antibody response. By transfecting P815 cell line P1.HTR with DNA of tum- variant P198, we obtained transfectants expressing tum- antigen P198 that could be identified on the basis of their ability to stimulate anti-P198 CTL. This was repeated with… CONTINUE READING
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